1-Aminocyclopropane-1-carboxylic acid CAS:22059-21-8

1-Aminocyclopropane-1-carboxylic Acid is a small molecule agonist at the glycine modulatory site of the NMDA receptor. Described to mimic the effects of glycine at the NMDAR, 1-Aminocyclopropane-1-carboxylic Acid competitively inhibits binding of [3H]glycine and enhances the binding of [3H]MK-801 to NMDAR-coupled cation channels similarly to glycine (though with less efficacy). 1-Aminocyclopropane-1-carboxylic Acid is shown to block convulsions and death produced by NMDA exposure, significantly reducing seizure induction and cell death of NMDA-treated hippocampal neurons.


Chemical formula
Molar mass 101.1 c

1-Aminocyclopropane-1-carboxylic acid (ACC) is a disubstituted cyclic α-amino acid in which a three-membered cyclopropane ring is fused to the Cα atom of the amino acid.


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